Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy of traditional Chinese exercises on cognitive function in older adults: a systematic review and meta-analysis of randomised controlled trials.

Age and ageing·2026

Same author

Questions of the future in aging and longevity research at the GIMM Festival.

Nature aging·2026

Same author

Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.

Aging cell·2026

Same author

Obesity and biological aging across the life course: A geroscience framework for metabolic health.

Metabolism: clinical and experimental·2026

Same author

Foundations of Gerophysics.

Aging·2026

Same author

Inferring Gene Regulatory Network Architecture Underlying Complex Traits: An Integrative Analysis of Mutant Lifespan and Gene Expression Profiles Identifies Master Regulators and Key Functional Modules for Yeast Aging.

Aging cell·2026

Same journal

Building a resilient ovarian reserve: Early soma-oocyte interactions.

Current topics in developmental biology·2026

Same journal

Role of macrophages in testis function.

Current topics in developmental biology·2026

Same journal

Role of retinoic acid in meiosis.

Current topics in developmental biology·2026

Same journal

Impact of cancer immunotherapies on oocyte health and ovarian function.

Current topics in developmental biology·2026

Same journal

The ovarian stroma as a key regulator of follicular development and gamete quality across the reproductive lifespan.

Current topics in developmental biology·2026

Same journal

Intercellular cyclic nucleotide dynamics mediate oocyte meiosis in mammalian preovulatory follicles.

Current topics in developmental biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 27, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Mouse models and aging: longevity and progeria.

Chen-Yu Liao¹, Brian K Kennedy¹

¹Buck Institute for Research on Aging, Novato, California, USA.

Current Topics in Developmental Biology

|June 21, 2014

Summary

This summary is machine-generated.

Genetic studies reveal insights into aging and longevity. Researchers evaluated genetic models with extended lifespans and those showing progeroid phenotypes to understand molecular aging processes.

Keywords:

Lifespan Longevity Mouse models Progeria

More Related Videos

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

Related Experiment Videos

Last Updated: Apr 27, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

Area of Science:

Gerontology
Genetics
Molecular Biology

Background:

Aging is a complex process influenced by multiple biological pathways.
Genetic research has successfully identified genes that modulate longevity.
Studies have extended to mammalian aging, using genetic models.

Purpose of the Study:

To detail and evaluate genetic models of aging.
To gain insights into molecular processes that modulate aging.
To assess if progeroid phenotypes accurately model accelerated aging.

Main Methods:

Review of genetic models with enhanced lifespan.
Evaluation of genetic interventions leading to progeroid phenotypes.
Analysis of molecular mechanisms underlying aging.

Main Results:

Identification of various genetic models exhibiting extended lifespan.
Observation of progeroid phenotypes resulting from genetic interventions.
Assessment of the relationship between progeroid pathologies and accelerated aging.

Conclusions:

Genetic models provide valuable insights into the molecular basis of aging.
Further evaluation is needed to determine the extent to which progeroid phenotypes mimic accelerated aging.
Understanding these genetic influences is key to modulating longevity.