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Central nervous system lymphoma: primary lumbar nerve root infiltration.
G C Toner1, R Holmes, R A Sinclair
1Department of Medical Oncology, Alfred Hospital, Melbourne, Australia.
Acta Haematologica
|January 1, 1989
Summary
Primary spinal cord lymphoma is rare, often spreading within the central nervous system (CNS). This case shows successful treatment of primary lymphoma affecting lumbar nerve roots with combined therapies.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Primary malignant lymphoma of the central nervous system (CNS) is a rare condition.
- Spinal cord involvement is infrequent and typically associated with widespread CNS disease.
Observation:
- A unique case of primary lymphoma infiltrating lumbar nerve roots without systemic involvement is presented.
- The patient experienced an excellent response to treatment.
Findings:
- Combined modality therapy, including radiotherapy and both intrathecal and intravenous cytotoxic agents, proved effective.
- The patient achieved a sustained recovery, remaining well and active 22 months post-diagnosis.
Implications:
- This case highlights the potential for successful management of primary spinal nerve root lymphoma.
- It underscores the efficacy of combined modality treatment for localized CNS lymphoma.
- Further review of literature on these rare tumors is provided.