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Published on: April 11, 2018
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Epigenetic regulation of persistent pain
Guang Bai1, Ke Ren1, Ronald Dubner1
1Program in Neuroscience, Department of Neural and Pain Sciences, University of Maryland Dental School, University of Maryland, Baltimore, MD.
Summary
Epigenetic regulation influences gene expression and plays a key role in persistent pain development and maintenance. Understanding these epigenetic mechanisms offers new therapeutic targets for chronic pain conditions.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Persistent or chronic pain is linked to environmental factors and altered gene expression in pain-signaling cells.
- Epigenetic regulation controls gene expression in response to environmental stimuli.
- Existing research suggests a role for epigenetics in the transition from acute to chronic pain.
Purpose of the Study:
- To explore the role of epigenetic regulation in the development and maintenance of persistent pain.
- To identify potential therapeutic strategies for chronic pain based on epigenetic mechanisms.
Main Methods:
- Review of recent animal model studies.
- Analysis of clinical studies.
Main Results:
- Epigenetic regulation is implicated in the development of persistent pain.
- Epigenetic mechanisms are involved in maintaining chronic pain states.
- Epigenetics may mediate the transition from acute to chronic pain.
Conclusions:
- Epigenetic regulation is a significant factor in persistent pain.
- Targeting epigenetic pathways presents a promising avenue for novel chronic pain therapeutics.
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