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Complex fractionated atrial electrograms related to left atrial wall thickness
Jin Wi1, Hye-Jeong Lee, Jae-Sun Uhm
1Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Journal of Cardiovascular Electrophysiology
|June 21, 2014
Summary
Thicker left atrial walls are associated with complex fractionated atrial electrograms (CFAE) in atrial fibrillation (AF) patients. This suggests left atrial wall thickness may contribute to CFAE mechanisms.
Area of Science:
- Cardiology
- Electrophysiology
Background:
- The mechanisms underlying complex fractionated atrial electrograms (CFAE) in atrial fibrillation (AF) are not fully understood.
- Investigating the relationship between CFAE and left atrial (LA) structural properties is crucial.
Purpose of the Study:
- To explore the association between left atrial wall thickness (LAWT) and the presence of CFAE in patients with AF.
- To determine if LAWT can predict CFAE locations.
Main Methods:
- Cardiac computed tomography was used to measure LAWT in 31 AF patients before catheter ablation.
- LAWT was assessed at 31 distinct locations within the left atrium.
- The number and location of CFAE sites were recorded.
Main Results:
- LA wall thickness varied significantly across different regions and patients (average 2.4 ± 0.4 mm).
- Significantly thicker LA walls were observed at CFAE sites (3.0 ± 1.0 mm) compared to non-CFAE sites (2.2 ± 0.9 mm).
- LAWT exceeding 2.5 mm predicted CFAE with 70% sensitivity and 70% specificity.
Conclusions:
- Left atrial wall thickness is strongly correlated with areas of CFAE.
- LAWT is a potential factor contributing to the generation or maintenance of CFAE in AF.
Keywords:
atrial fibrillationatriumcatheter ablationcomplex fractionated atrial electrogrampulmonary vein isolationMore Related Videos
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