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Central nervous system activity of an aqueous acetonic extract of Ficus carica L. in mice
Mittal M Bhanushali1, Dinesh T Makhija1, Yadunath M Joshi1
1Bharati Vidyapeeth's College of Pharmacy, Belapur, Navi Mumbai, Maharashtra, India.
Background:
Ficus carica Linn. is reported to possess variety of activities, but its potential in CNS disorders is still to be explored.
Objective:
The present study was carried out to evaluate the CNS depressant activity of aqueous acetonic extract of Ficus carica Linn on different models in mice.
Materials And Methods:
The aerial parts of the plant Ficus carica L. were extracted with aqueous acetone and the solvent was removed by rotary vacuum evaporator under reduced pressure. A crude extract was given orally and its effects were tested on ketamine-induced sleeping time, muscle-coordination, anxiety (elevated-plus maze and Staircase test), convulsions [maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures], and nociception. In addition, we determined the levels of neurotransmitters, norepinephrine (NE) and 5-hydroxytryptamine (5-HT).
Results:
RESULTS FROM THE EXPERIMENTAL MODELS TESTED SHOWED: (1) a delay on onset and prolongation of sleep of ketamine-induced sleeping time; (2) significant muscle relaxant activity; (3) a significant attenuation in the anxiety-response (4) a delay in the onset of seizures and reduction in duration of seizures and mortality induced by MES and PTZ; (5) a reduction in the licking time in nociception test and (6) increased levels of NE and 5-HT.
Conclusion:
This suggests that Ficus carica L. exerts its CNS depressive effect by modulating the neurotransmitters NE and 5-HT in the brain.
