Related Experiment Video
Updated: Apr 27, 2026

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Simple patch closure for perforated peptic ulcer in children followed by helicobacter pylori eradication
Turan Yildiz1, Huri Tilla Ilce2, Canan Ceran3
1Turan Yildiz, Department of Pediatric Surgery, Sakarya University Medical Schools, Sakarya, Turkey.
Insights
Pediatric peptic ulcer perforation is rare but treatable. The modified Graham technique for duodenal ulcer repair combined with Helicobacter Pylori eradication therapy offers a safe and effective treatment for children.
Area of Science:
- Pediatric Surgery
- Gastroenterology
Background:
- Peptic ulcer disease is uncommon in children, often leading to delayed diagnosis and complications like perforation.
- Limited data exists on surgical interventions for perforated duodenal ulcers in pediatric patients.
Purpose of the Study:
- To report the experience with the modified Graham technique for perforated duodenal ulcers in children.
- To review literature on surgical procedures and outcomes for pediatric perforated duodenal ulcers.
Main Methods:
- Retrospective evaluation of nine pediatric patients undergoing surgery for perforated duodenal ulcers over eight years.
- Analysis of patient demographics, symptoms, admission time, operative findings, and postoperative course.
- Review of relevant medical literature.
Main Results:
- Nine children (mean age 13.2 years) with perforated duodenal ulcers were treated.
- All perforations were on the anterior duodenum, repaired with primary suturing and Graham patch omentoplasty.
- Uneventful recovery in all patients; five tested positive for Helicobacter Pylori and received triple therapy.
Conclusions:
- Perforated peptic ulcers should be suspected in children with acute abdominal pain and peritoneal signs.
- The modified Graham technique and postoperative triple therapy for Helicobacter Pylori are safe and effective for pediatric peptic ulcer perforation.
Objective:
Peptic ulcer disease in children is rare. Therefore, the diagnosis can be missed until complications such as perforation or hemorrhage occur. Few reports have investigated the procedures and outcomes of children who have undergone operations for perforated duodenal ulcers. We report our experience with the modified Graham technique for perforated duodenal ulcers in nine children and review the literature. Methods : The records of patients operated on for a perforated duodenal ulcer in the last 8 years in two pediatric surgery centers were evaluated retrospectively. Patient demographics, symptoms, time to admission to hospital, operative findings, and postoperative clinical course were evaluated. Results : Nine children (mean age 13.2 years, range 6-170 years) were included. All patients were admitted in the first six hours after their abdominal pain started. In three patients, there was free air on plain x-rays, while the x-rays were normal in six. All perforations were located on the anterior surface of the first part of the duodenum and repaired with primary suturing and Graham patch omentoplasty. The recovery was uneventful in all patients. In five patients, urea breath tests were performed postoperatively for Helicobacter Pylori, and the results were positive. All patients underwent triple therapy with lansoprazole, amoxicillin, and clarithromycin. The mean follow-up time was 58 (range 3-94) months. Conclusions : Peptic ulcer perforation should be suspected in children who have acute abdominal pain and peritoneal signs, especially when their suffering is intense. The simple patch repair and postoperative triple therapy for Helicobacter Pylori are safe and satisfactory for treating peptic ulcer perforation in children.
Related Concept Videos
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease
Peptic Ulcer
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction

