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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
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Hydatidiform mole and subsequent pregnancy outcome: a population-based cohort study
Ulrika Joneborg1, Sandra Eloranta2, Anna L V Johansson2
1Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska University Hospital/Institutet, Stockholm, Sweden.
American Journal of Obstetrics and Gynecology
|June 21, 2014
Summary
Women with a history of hydatidiform mole (HM) face no increased maternal risks in future pregnancies. However, they have a slightly higher risk of preterm birth, large-for-gestational-age, and stillbirth, though overall risks remain low.
Area of Science:
- Reproductive Medicine
- Perinatal Epidemiology
- Obstetrics
Background:
- Hydatidiform mole (HM) is a gestational trophoblastic disease.
- Understanding risks in subsequent pregnancies after HM is crucial for patient counseling and management.
Purpose of the Study:
- To determine if a history of hydatidiform mole (HM) increases the risk of adverse outcomes in subsequent pregnancies.
Main Methods:
- Nationwide cohort study using Swedish Medical Birth Register data (1973-2009).
- Compared adverse pregnancy outcomes in women with a history of HM versus those without.
- Adjusted for maternal age and country of birth.
Main Results:
- No increased risk of adverse maternal outcomes observed.
- Increased risk of preterm birth (OR 1.23) in women with prior HM.
- Increased risk of large-for-gestational-age birth (OR 1.35) and stillbirth (OR 1.81) if at least one birth occurred between HM and index pregnancy.
- Risk of repeat mole was 0.4%.
Conclusions:
- Women with a history of HM do not face higher risks for adverse maternal outcomes in subsequent pregnancies.
- There is an elevated risk for specific adverse offspring outcomes: large-for-gestational-age birth, stillbirth, and preterm birth.
- Absolute risks for these subsequent adverse offspring outcomes are low.
