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Related Concept Videos

Cells of the Epidermis01:24

Cells of the Epidermis

7.2K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Layers of the Epidermis01:21

Layers of the Epidermis

9.7K
The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
9.7K
Papillary Dermis01:11

Papillary Dermis

5.8K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.8K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.4K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Cellular Adaptation III: Hyperplasia01:26

Cellular Adaptation III: Hyperplasia

48
Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...
48
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

2.9K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Related Experiment Video

Updated: Apr 27, 2026

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
10:51

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

Published on: July 14, 2017

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AHR: making the keratinocytes thick skinned.

Marco Colonna1

  • 1Washington University School of Medicine, St. Louis, MO, USA.

Immunity
|June 21, 2014
PubMed
Summary

The aryl hydrocarbon receptor (AhR) in skin keratinocytes helps prevent psoriasis. This transcription factor responds to environmental cues to suppress psoriatic lesions, offering a potential therapeutic target.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Psoriasis is a chronic inflammatory skin disease.
  • Skin homeostasis is disrupted by external and internal signals.
  • The aryl hydrocarbon receptor (AhR) is involved in environmental responses.

Purpose of the Study:

  • To investigate the role of AhR in keratinocytes in the context of psoriasis.
  • To determine if AhR signaling can suppress psoriatic lesions.

Main Methods:

  • The study by Di Meglio et al. (2014) focused on AhR's function in keratinocytes.
  • Investigated the impact of AhR on the development of psoriatic lesions.

Main Results:

  • AhR acts as a suppressor of psoriatic lesions.

More Related Videos

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis
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Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis

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Generation and Culturing of Primary Human Keratinocytes from Adult Skin
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Generation and Culturing of Primary Human Keratinocytes from Adult Skin

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Related Experiment Videos

Last Updated: Apr 27, 2026

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
10:51

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

Published on: July 14, 2017

31.7K
Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis
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Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis

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Generation and Culturing of Primary Human Keratinocytes from Adult Skin
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Generation and Culturing of Primary Human Keratinocytes from Adult Skin

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  • Environmental-responsive AhR signaling in keratinocytes is crucial for preventing psoriasis.

    • Conclusions:

    • AhR signaling in keratinocytes plays a protective role against psoriasis.
    • Targeting AhR may offer a novel therapeutic strategy for psoriasis treatment.