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Related Experiment Video

Updated: Apr 27, 2026

Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice

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Digital ischaemia in the digital age.

M Elmussareh¹, Ca Hart¹, A Khanna¹

¹Leicester Royal Infirmary, Leicester, UK.

Journal of Surgical Case Reports

|June 21, 2014

Summary

Accidental epinephrine injection in digits can cause ischemia. Phentolamine administration, identified via a Google search, rapidly reversed these symptoms, showcasing the internet's value in evidence-based medical practice.

Area of Science:

Emergency Medicine
Pharmacology

Background:

Accidental digital injection of epinephrine can lead to severe ischemia.
Initial management strategies for this complication were unsuccessful in this case.

Purpose of the Study:

To identify an effective treatment strategy for epinephrine-induced digital ischemia.
To evaluate the utility of online resources in managing unfamiliar medical emergencies.

Main Methods:

A Google search was conducted to find information on managing epinephrine digital injection.
Literature review identified phentolamine as a potential treatment.
Phentolamine was administered to the affected digit.

Main Results:

Ischaemic symptoms showed an almost immediate reversal following phentolamine administration.

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The intervention successfully restored blood flow and resolved ischemia.

Conclusions:

Phentolamine is an effective antidote for epinephrine-induced digital ischemia.
The internet serves as a valuable tool for real-time information retrieval and evidence-based decision-making in clinical practice.