Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

9.6K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
9.6K
Hematopoiesis01:21

Hematopoiesis

8.1K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.4K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
Production of Formed Elements01:34

Production of Formed Elements

7.3K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
7.3K
Lineage Commitment01:21

Lineage Commitment

3.4K
Commitment is the  process whereby stem cells:
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features.

Nature communications·2026
Same author

Balancing act: how Apelin tunes vascular and haemogenic identities.

EMBO reports·2026
Same author

Lack of Evidence for European Eel Infection by Anguillicola crassus in Madeira Island, Macaronesia.

Journal of fish diseases·2024
Same author

ADA2 regulates inflammation and hematopoietic stem cell emergence via the A<sub>2b</sub>R pathway in zebrafish.

Communications biology·2024
Same author

Protocol for the analysis of hematopoietic lineages in the whole kidney marrow of adult zebrafish.

STAR protocols·2024
Same author

LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition.

Developmental biology·2023

Related Experiment Video

Updated: Apr 27, 2026

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis
07:38

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis

Published on: November 3, 2017

8.0K

Developmental hematopoiesis: ontogeny, genetic programming and conservation.

Aldo Ciau-Uitz1, Rui Monteiro2, Arif Kirmizitas1

  • 1MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

Experimental Hematology
|June 21, 2014
PubMed
Summary
This summary is machine-generated.

Understanding hematopoietic stem cell (HSC) programming is key for regenerative medicine. Zebrafish and Xenopus models reveal early developmental steps, aiding future HSC generation from pluripotent stem cells.

More Related Videos

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

10.8K
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
11:42

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

Published on: November 4, 2019

7.5K

Related Experiment Videos

Last Updated: Apr 27, 2026

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis
07:38

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis

Published on: November 3, 2017

8.0K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

10.8K
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
11:42

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

Published on: November 4, 2019

7.5K

Area of Science:

  • Developmental biology
  • Hematopoiesis
  • Regenerative medicine

Background:

  • Hematopoietic stem cells (HSCs) are crucial for lifelong blood production and regenerative medicine.
  • Generating HSCs from pluripotent stem cells is hindered by incomplete understanding of their programming.
  • HSCs originate during embryogenesis in the dorsal aorta (DA) from hemogenic endothelium via the endothelial-to-hematopoietic transition.

Purpose of the Study:

  • To elucidate the early developmental events preceding the endothelial-to-hematopoietic transition in HSC specification.
  • To highlight the contributions of zebrafish and Xenopus models in understanding HSC programming.
  • To provide insights for generating HSCs from naïve pluripotent cells.

Main Methods:

  • Comparative analysis of developmental hematopoiesis in zebrafish and Xenopus embryos.
  • Review of lineage tracing experiments in Xenopus.
  • In vivo imaging of blood cell development in zebrafish.

Main Results:

  • Zebrafish and Xenopus embryos facilitate understanding of early HSC programming from lateral plate mesoderm to hemogenic endothelium.
  • Xenopus lineage tracing distinguishes embryonic and adult hematopoiesis origins.
  • Zebrafish imaging visualizes HSC emergence in the DA.

Conclusions:

  • Model organisms like zebrafish and Xenopus are invaluable for studying developmental hematopoiesis.
  • Understanding early progenitor specification is essential for clinical HSC generation.
  • Further research in these models will advance regenerative medicine applications.