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Mixed valence copper(I,II) binuclear complexes with unexpected structure: synthesis, biological properties and
Alexander G Majouga1, Maria I Zvereva, Maria P Rubtsova
1Department of Chemistry, Lomonosov Moscow State University , Leninskie Gory, 1/3, 119991 Moscow, Russian Federation.
Abstract:
We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.
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