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Updated: Apr 27, 2026

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Pseudo-lyre sign.

R Nash1, R Farrell1

  • 1Northwick Park Hospital, London, UK.

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|June 21, 2014
PubMed
Summary
This summary is machine-generated.

A rare vagal paraganglioma mimicked the characteristic "Lyre Sign" typically seen in carotid body tumors. This case highlights the importance of considering atypical presentations for accurate diagnosis of neck tumors.

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Area of Science:

  • Vascular Surgery
  • Neurosurgery
  • Oncology

Background:

  • Carotid body tumors characteristically cause internal and external carotid artery splaying, termed the 'Lyre Sign'.
  • Vagal paragangliomas are uncommon neuroendocrine tumors originating from the vagus nerve's paraganglionic cells.
  • Accurate differentiation of neck masses is crucial for appropriate management.

Purpose of the Study:

  • To report a unique case of a vagal paraganglioma presenting with the 'Lyre Sign'.
  • To discuss the diagnostic challenges posed by this atypical presentation.
  • To emphasize the differential diagnosis of carotid bifurcation masses.

Main Methods:

  • Case presentation with detailed clinical history and imaging findings.
  • Review of relevant literature on carotid body tumors and vagal paragangliomas.
  • Discussion of radiological and pathological features.

Main Results:

  • A vagal paraganglioma at the carotid bifurcation mimicked the 'Lyre Sign' on imaging.
  • The tumor's location and appearance led to initial diagnostic uncertainty.
  • Histopathological confirmation identified the mass as a vagal paraganglioma.

Conclusions:

  • Vagal paragangliomas can present atypically, mimicking the 'Lyre Sign' of carotid body tumors.
  • Radiological features alone may be insufficient for definitive diagnosis.
  • Consideration of rare differentials is essential for managing complex neck masses.