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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

51
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Related Experiment Video

Updated: Apr 27, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Paraproteinemic maculopathy.

Ahmad M Mansour1, J Fernando Arevalo2, Josep Badal3

  • 1Departments of Ophthalmology, American University of Beirut and Rafic Hariri University Hospital, Beirut, Lebanon.

Ophthalmology
|June 22, 2014
PubMed
Summary
This summary is machine-generated.

Paraproteinemic maculopathy, an uncommon ocular manifestation of monoclonal gammopathy, can be unilateral. Systemic reduction of immunoglobulin levels is key to treating this condition.

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Area of Science:

  • Ophthalmology
  • Hematology
  • Immunology

Background:

  • Paraproteinemia, characterized by pathological monoclonal antibodies, can uncommonly manifest as serous macular detachment.
  • Understanding the clinical course and therapeutic outcomes of paraproteinemic maculopathy is crucial for patient management.

Observation:

  • A retrospective study reviewed 33 cases of paraproteinemia with serous macular detachment, analyzing clinical data, rheology, and optical coherence tomography (OCT) findings.
  • Key data included best-corrected visual acuity (BCVA), macular detachment characteristics, and systemic/local therapies employed.
  • Coexisting conditions like diabetes, hypertension, and anemia were noted, along with immunoglobulin levels and blood viscosity.

Findings:

  • Systemic therapies, including plasmapheresis and chemotherapy, aimed to normalize immunoglobulin levels, achieving normalization in 8 patients.
  • Maculopathy resolved partially or completely in 17 patients after a median follow-up of 7 months, while 14 showed no change or worsening.
  • Unilateral maculopathy was observed in 9 cases, and diabetic patients presented with maculopathy at lower initial immunoglobulin levels. A positive correlation existed between detachment area and serum viscosity.

Implications:

  • The primary therapeutic goal for paraproteinemic maculopathy is systemic reduction of immunoglobulin levels.
  • Systemic routes are effective for achieving this goal, offering a viable treatment strategy.
  • Diabetes mellitus may influence immunoglobulin leakage, suggesting a potential role in disease presentation and progression.