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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

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Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
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Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
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MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
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Factors Affecting Drug Distribution: Organ Perfusion Rate01:15

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Drug distribution within the body is a complex process influenced by several factors, including perfusion rate, the rate at which the bloodstream transports drugs to tissue. This limitation becomes particularly significant when dealing with highly lipophilic drugs. In such cases, the rate at which the drug can move across membranes is crucial, and if the membrane is highly permeable to the drug, distribution becomes rate-limited by perfusion.
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Related Experiment Video

Updated: Feb 7, 2026

Porcine Normothermic Isolated Liver Perfusion
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Ischemia/reperfusion during normothermic perfusion.

X Tillou1, R Thuret2, A Doerfler1

  • 1Urology and Transplantation department, University Hospital, Caen, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|June 22, 2014
PubMed
Summary
This summary is machine-generated.

Normothermic kidney preservation shows promise, challenging traditional cold storage methods. Techniques like normothermic perfusion offer a more physiological approach for organ preservation and transplantation.

Keywords:
Ex vivo normothermic reperfusionIschemic normothermic preconditioningIschemic postconditioningPharmacologic normothermic preconditioningPost-conditionnement ischémiquePreconditionnement normothermique ischémiquePreconditionnement normothermique pharmacologiqueRemote ischemic transplantation preconditioningReperfusion normothermqiue ex-vivo

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Area of Science:

  • Nephrology
  • Transplantation immunology
  • Organ preservation science

Background:

  • Current cold storage methods for organ preservation face limitations, particularly for extended criteria donors and donation after cardiac death.
  • Advancements in normothermic kidney preservation are crucial for improving transplant outcomes.

Purpose of the Study:

  • To review recent findings and perspectives in normothermic kidney preservation.
  • To evaluate alternative methods to cold ischemia for organ storage.

Main Methods:

  • A comprehensive literature review was conducted using PubMed.
  • Keywords included: cold ischemia, warm ischemia, normothermic, organ preservation, preconditioning, and organ perfusion.

Main Results:

  • Identified several kidney preservation strategies: normothermic preconditioning (ischemic and pharmacologic), ex vivo normothermic reperfusion, remote ischemic preconditioning, and postconditioning.
  • Clinical applications currently involve Extra Corporeal Membrane Oxygenation (ECMO) for preconditioning or ex vivo normothermic perfusion.

Conclusions:

  • Normothermic preservation methods present promising experimental and clinical results, challenging the dominance of cold preservation.
  • Normothermic perfusion and conservation using autologous oxygenated blood via ECMO or Regional Normothermic Circulation appear to be the most physiological and suitable methods.