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Updated: Apr 27, 2026
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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
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Intensive care in patients with lung cancer: a multinational study
M Soares1, A-C Toffart2, J-F Timsit3
1Post-Graduation Program, Instituto Nacional de Câncer, Rio de Janeiro; Department of Clinical Research, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Summary
Lung cancer patients in intensive care units (ICUs) with good performance status and non-progressive disease have meaningful survival. Poor performance status and advanced cancer predict high mortality, suggesting palliative care may be best.
Area of Science:
- Oncology
- Critical Care Medicine
- Epidemiology
Background:
- Limited data exists on intensive care unit (ICU) outcomes for lung cancer patients, primarily from single-center studies.
- This study aimed to analyze clinical characteristics and outcomes of lung cancer patients admitted to ICUs.
Purpose of the Study:
- To evaluate the clinical characteristics and outcomes of lung cancer patients admitted to intensive care units (ICUs).
- To identify factors associated with mortality in this patient population.
Main Methods:
- A prospective, multicenter study involving 449 lung cancer patients across 22 ICUs in Europe and South America in 2011.
- Multivariate Cox proportional hazards frailty models were used to determine predictors of 30-day and 6-month mortality.
Main Results:
- Most patients (71%) had newly diagnosed lung cancer, with 56% experiencing cancer-related complications.
- Hospital, 30-day, and 6-month mortality rates were 39%, 41%, and 55%, respectively.
- Key mortality predictors included organ dysfunction severity, poor performance status (PS), recurrent/progressive cancer, and cancer-related complications.
Conclusions:
- ICU admission offers meaningful survival for lung cancer patients with good PS and non-recurrent/progressive disease.
- High mortality rates were observed in patients with poor PS or those unfit for anticancer treatment, indicating palliative care as a potential option.
- High-volume centers demonstrated lower mortality rates.
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