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Sin3b interacts with Myc and decreases Myc levels

Pablo Garcia-Sanz1, Andrea Quintanilla2, M Carmen Lafita2

  • 1From the Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas, Universidad de Cantabria, Sociedad para el Desarrollo de Cantabria and the Departamento de Biología Molecular, Universidad de Cantabria, Santander 39011, Spain, the Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas, Instituto de Investigación Hospital Universitario La Paz (IdiPaz), Facultad de Medicina, Universidad Autónoma de Madrid, 28046 Madrid, Spain, the Fundación M. D. Anderson Internacional, Madrid, Spain.

The Journal of Biological Chemistry
|June 22, 2014
PubMed
Summary

The transcriptional repressor Sin3b interacts with Myc protein, decreasing Myc levels through deacetylation and repression. Low Sin3b expression correlates with cancer progression, suggesting Sin3b limits Myc activity.

Keywords:
Breast CancerGene ExpressionHistone Deacetylase (HDAC)Myc (c-Myc)Sin3bTranscription

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