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Updated: Apr 27, 2026

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
15:43

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes

Published on: January 7, 2013

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PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function

Mark W Sims, James Winter, Sean Brennan

    American Journal of Physiology. Heart and Circulatory Physiology
    |June 22, 2014
    PubMed
    Summary

    High blood glucose levels after myocardial infarction (MI) directly harm heart cells (cardiomyocytes) by activating specific protein kinase C (PKC) enzymes. Inhibiting PKCα and β protects heart cells and restores protective mechanisms.

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