Related Experiment Video

Updated: Apr 27, 2026

Long-term Blood Pressure Measurement in Freely Moving Mice Using Telemetry
07:54

Long-term Blood Pressure Measurement in Freely Moving Mice Using Telemetry

Published on: May 17, 2016

20.2K

Top 10 landmark studies in hypertension

Elizabeth W Edwards1, Donald J DiPette1, Raymond R Townsend2

  • 1Department of Medicine, University of South Carolina School of Medicine, Columbia, SC, USA.

Journal of the American Society of Hypertension : JASH
|June 23, 2014
PubMed

Insights

Over 70 years, understanding of hypertension has shifted from acceptance to recognizing its risks. Key studies now guide physicians on managing blood pressure, treatment goals, and outcomes for all patients.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Endocrinology

Background:

  • Hypertension management has evolved significantly over 70 years.
  • Elevated blood pressure was once considered a normal part of aging.
  • Current evidence links high blood pressure to significant cardiovascular risks.

Purpose of the Study:

  • To review pivotal studies in hypertension management.
  • To highlight research that changed physician attitudes towards treating hypertension.
  • To provide an overview of key advancements in understanding and treating high blood pressure.

Main Methods:

  • Literature review of 10 selected studies.
  • Focus on studies influencing physician attitudes on hypertension management.
  • Categorization of studies by topic: treatment initiation, pharmacologic agents, and special populations.

Main Results:

  • Identified 10 landmark studies impacting hypertension care.
  • Studies cover critical areas: blood pressure goals, drug comparisons, and management in diabetes and kidney disease.
  • Demonstrated a shift in medical understanding and treatment approaches for hypertension.

Conclusions:

  • Physicians' attitudes towards hypertension have been reshaped by key research.
  • Evidence-based guidelines now emphasize aggressive blood pressure management.
  • Optimal hypertension control is crucial for reducing cardiovascular morbidity and mortality, especially in patients with diabetes and chronic kidney disease.

Keywords:
Blood pressureclinical trials

More Related Videos

Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats07:35

Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats

Published on: January 31, 2019

15.4K
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

17.8K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
851
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.8K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
1.2K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.7K
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
682
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
992