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[Hypertension, chronic kidney disease and genetics in patients with African ancestry]

J-M Halimi1

  • 1Service de néphrologie-immunologie clinique, hôpital Bretonneau, EA 4245, université François-Rabelais, 2, boulevard Tonnellé, 37000 Tours, France.

Annales De Cardiologie Et D'Angeiologie
|June 23, 2014
PubMed

Insights

Hypertension and kidney disease disproportionately affect African Americans. Recent genetic and infectious disease research explains these disparities, offering new insights into hypertension

Area of Science:

  • Nephrology
  • Genetics
  • Infectious Diseases

Background:

  • African Americans exhibit higher rates of hypertension compared to Caucasians.
  • End-stage renal disease (ESRD) is more prevalent in African Americans, irrespective of blood pressure management.
  • Increased ESRD risk in African Americans is observed with HIV infection or lupus.

Purpose of the Study:

  • To elucidate the underlying reasons for elevated hypertension and ESRD incidence in African Americans.
  • To explain how recent genetic and infectious disease research has reshaped understanding of these health disparities.

Main Methods:

  • Review of recent genetic studies.
  • Analysis of infectious disease research findings.
  • Synthesis of data to explain hypertension and ESRD disparities in African Americans.

Main Results:

  • Genetic factors contribute to hypertension susceptibility in African Americans.
  • Specific infectious agents and host-pathogen interactions influence renal outcomes.
  • These factors collectively explain the higher burden of hypertension and ESRD in this population.

Conclusions:

  • Recent advances in genetics and infectious diseases provide a clearer understanding of hypertension and kidney disease disparities in African Americans.
  • This knowledge is crucial for developing targeted prevention and treatment strategies.

Keywords:
Afro-AmericanApolipoproteinApolipoprotéineChronic renal diseaseGeneticGénétiqueHypertensionInsuffisance rénale chroniqueSujets noirsTrypanosomiaseTrypanosomiasis

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