[New spirometric reference equations for healthy Chilean adults]

Area of Science:

• Pulmonary Medicine
• Biostatistics
• Population Health

Context:

• Accurate interpretation of spirometry requires population-specific reference values.
• Existing spirometric equations show limitations for the Chilean population, particularly for adults over 65.
• This study addresses the need for updated reference values in Chile.

Purpose:

• To establish new, accurate spirometric reference values for Chilean adults.
• To base these values on national data from healthy, non-smoking individuals.
• To improve the diagnostic accuracy of spirometry in Chile.

Summary:

• A comprehensive database of spirometric data was created from five Chilean population-based studies.
• Spirometries from 448 males and 726 females were analyzed using multiple regression models.
• New reference values and lower limits of normality (LLN) were calculated for FEV1, FVC, FEV1/FVC, and FEF25-75.

Impact:

• The newly developed equations demonstrate a superior fit compared to current reference values used in Chile.
• These findings support the adoption of the new reference values for improved clinical interpretation.
• Enhanced spirometric assessment can lead to better diagnosis and management of respiratory conditions in Chile.