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Related Concept Videos

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Such synergistic combinations...
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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
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Clinical Significance of Antibiotic Resistance01:25

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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
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Updated: Apr 27, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
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Finding alternatives to antibiotics.

Heather K Allen1, Julian Trachsel, Torey Looft

  • 1United States Department of Agriculture, Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, Agricultural Research Service, Ames, Iowa.

Annals of the New York Academy of Sciences
|June 24, 2014
PubMed
Summary
This summary is machine-generated.

New treatments are needed for antibiotic-resistant pathogens. Alternatives like phage therapy and microbial modulation offer promising disease prevention and treatment strategies, complementing antibiotics.

Keywords:
antibiotic alternativesantibiotic prudencybacteriocinsgut microbiotaphage therapypredatory bacteria

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Rising antibiotic resistance necessitates novel therapeutic strategies.
  • Declining antibiotic development pipelines create an urgent need for alternatives.
  • Distinguishing between disease prevention and treatment is crucial for effective interventions.

Purpose of the Study:

  • To review and discuss non-antibiotic approaches for combating antibiotic-resistant pathogens.
  • To explore methods for disease prevention and treatment in animal agriculture and human medicine.
  • To evaluate the potential of emerging therapies to augment or replace antibiotics.

Main Methods:

  • Review of current literature on antibiotic resistance and alternative treatments.
  • Categorization of interventions into disease prevention (e.g., gut microbial modulation) and treatment (e.g., phage therapy, bacteriocins).
  • Analysis of how these alternatives impact bacterial killing and resistance selection.

Main Results:

  • Gut microbial modulation (feed additives, fecal transplantation) shows promise for disease prevention.
  • Phage therapy, phage lysins, bacteriocins, and predatory bacteria are viable treatment options.
  • Several alternative methods enhance antibiotic efficacy and reduce resistance selection.

Conclusions:

  • Non-antibiotic strategies are essential for managing antibiotic resistance in human and animal health.
  • A combination of antibiotics and alternatives, used judiciously, is key to long-term efficacy.
  • Continued research and development of these alternatives are critical for future infectious disease control.