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Extracardiac birth defects in children with congenital heart defects

Sunil Karande1, Varsha Patil, Archana Kher

  • 1Genetic Clinic, Department of Pediatrics, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India. Correspondence to: Dr Sunil Karande, Professor, Department of Pediatrics, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400 012, India. karandesunil@yahoo.com.

Indian Pediatrics
|June 24, 2014
PubMed

Insights

Extracardiac birth defects are common in children with congenital heart defects (CHDs). This study found that 17.5% of children with CHDs had these additional defects, with craniofacial and skeletal issues being most frequent.

Area of Science:

  • Pediatric Cardiology
  • Medical Genetics
  • Developmental Biology

Background:

  • Congenital heart defects (CHDs) are a significant cause of infant mortality and morbidity.
  • Extracardiac birth defects (ECBDs) can complicate the management and outcomes of children with CHDs.
  • Understanding the prevalence and patterns of ECBDs is crucial for comprehensive care.

Purpose of the Study:

  • To determine the frequency and types of extracardiac birth defects in children diagnosed with congenital heart defects.
  • To analyze the pattern of these associated defects in a tertiary care setting.

Main Methods:

  • A cross-sectional observational study was conducted.
  • Data was collected from January 2010 to June 2011.
  • Included 560 children with congenital heart defects.

Main Results:

  • Nearly one-fifth (17.5%) of children with CHDs presented with extracardiac birth defects.
  • A total of 386 ECBDs were identified, comprising 103 major and 283 minor defects.
  • Craniofacial and skeletal anomalies were the most prevalent types of ECBDs, with 36 cases of syndromic conditions and 6 with laterality defects.

Conclusions:

  • Extracardiac birth defects are a frequent comorbidity in pediatric patients with congenital heart defects.
  • The findings highlight the importance of thorough screening for ECBDs in children with CHDs.
  • Early identification and management of ECBDs can improve patient outcomes.
Abstract

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