Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatitis01:25

Hepatitis

80
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
80

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extracellular vesicles in molecular crosstalk and disease pathogenesis: a comprehensive review on mechanisms and therapeutic prospects.

Biochemical pharmacology·2026
Same author

Deletion of phosphatidylethanolamine methyltransferase promotes the spontaneous development of hepatic steatosis, inflammation, and fibrosis in young mice.

Clinical science (London, England : 1979)·2026
Same author

Beyond diabetes and obesity: GLP-1 receptor agonists as multifunctional therapeutics across the steatotic liver disease spectrum.

Frontiers in pharmacology·2026
Same author

Hepatocyte-Specific Deletion of Betaine-Homocysteine Methyltransferase Disrupts Methionine Metabolism and Promotes the Spontaneous Development of Hepatic Steatosis.

Biomolecules·2026
Same author

Exploring the disease burden and quality of life in patients with short bowel syndrome with intestinal failure: Insights from exit interviews in the glepaglutide EASE SBS-1 phase 3 trial.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2026
Same author

Hepatitis B virus, alcohol, and liver cancer.

Frontiers in oncology·2026

Related Experiment Video

Updated: Apr 27, 2026

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
11:44

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

10.5K

Ethanol affects hepatitis C pathogenesis: humanized SCID Alb-uPA mouse model.

Natalia A Osna1, Kusum K Kharbanda1, Yimin Sun2

  • 1Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, USA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, USA.

Biochemical and Biophysical Research Communications
|June 24, 2014
PubMed
Summary

Ethanol consumption worsens alcoholic liver injury and hinders hepatitis C virus (HCV) clearance in a novel mouse model. This study highlights ethanol

Keywords:
AlcoholHepatitis C virusOxidative stressProteasome activitySCID Alb-uPA mice

More Related Videos

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

21.6K
Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
10:12

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Published on: September 11, 2019

7.9K

Related Experiment Videos

Last Updated: Apr 27, 2026

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
11:44

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

10.5K
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

21.6K
Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
10:12

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Published on: September 11, 2019

7.9K

Area of Science:

  • Hepatology
  • Virology
  • Toxicology

Background:

  • Alcohol consumption exacerbates hepatitis C virus (HCV) infection outcomes.
  • Lack of suitable in vivo models hinders HCV-ethanol research.
  • Ethanol's impact on HCV progression requires further investigation.

Purpose of the Study:

  • To evaluate the effects of ethanol exposure on HCV infection in a chimeric mouse model.
  • To assess if ethanol exacerbates liver pathology and viral persistence in HCV-infected mice.

Main Methods:

  • Chimeric SCID Alb-uPA mice transplanted with human hepatocytes were infected with HCV.
  • Mice were fed either a control diet (chow+water) or an ethanol diet (chow+20% ethanol).
  • Biochemical and histological changes, along with HCV RNA levels, were monitored over 5 weeks.

Main Results:

  • Ethanol-fed mice exhibited increased oxidative stress, decreased proteasome activity, and enhanced steatosis.
  • HCV RNA was cleared in control mice after 5 weeks.
  • HCV RNA persisted in ethanol-fed mice, with levels remaining similar or increasing.

Conclusions:

  • Ethanol exposure in this model induces changes consistent with alcoholic liver injury.
  • Ethanol feeding delays HCV RNA clearance, promoting persistent infection and liver injury.
  • This chimeric mouse model is suitable for studying HCV-ethanol interactions.