Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anorexia Nervosa01:28

Anorexia Nervosa

2.0K
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
2.0K
Bulimia Nervosa01:30

Bulimia Nervosa

1.1K
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
1.1K
Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

3.0K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
3.0K
Body Water Content and Fluid Compartments01:19

Body Water Content and Fluid Compartments

4.1K
Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions...
4.1K
Hypodermis01:02

Hypodermis

7.7K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meeting Future Demands of Acute Care Through the Home Hospital Care Model.

Journal of healthcare management / American College of Healthcare Executives·2025
Same author

Low oxytocin levels are broadly associated with more pronounced psychopathology in anorexia nervosa with primarily restricting but not binge/purge eating behavior.

Frontiers in endocrinology·2023
Same author

Physiologic Transdermal Estradiol Replacement Mimics Effects of Endogenous Estrogen on Bone Outcomes in Hypoestrogenic Women with Anorexia Nervosa.

Nutrients·2022
Same author

High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors.

Frontiers in oncology·2022
Same author

Sprouting Angiogenesis in Human Pituitary Adenomas.

Frontiers in oncology·2022
Same author

The effect of short-term high-caloric feeding and fasting on bone microarchitecture.

Bone·2021

Related Experiment Video

Updated: Apr 27, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.5K

Marrow fat composition in anorexia nervosa.

Miriam A Bredella1, Pouneh K Fazeli2, Scott M Daley1

  • 1Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Bone
|June 24, 2014
PubMed
Summary
This summary is machine-generated.

Women with anorexia nervosa have increased femoral marrow fat. Higher marrow fat saturation inversely correlates with bone mineral density, suggesting potential negative effects on bone quality.

Keywords:
Anorexia nervosaBone marrow fatMR spectroscopyMarrow fat compositionSaturated lipids

More Related Videos

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
10:28

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

15.8K
Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research
06:48

Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research

Published on: June 7, 2024

2.4K

Related Experiment Videos

Last Updated: Apr 27, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.5K
Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
10:28

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

15.8K
Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research
06:48

Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research

Published on: June 7, 2024

2.4K

Area of Science:

  • Bone Metabolism
  • Body Composition Analysis
  • Magnetic Resonance Imaging

Background:

  • Anorexia nervosa (AN) is associated with increased marrow fat despite overall body fat depletion.
  • Marrow fat composition is a potential biomarker for bone quality.

Purpose of the Study:

  • Investigate femoral marrow fat composition using proton MR spectroscopy ((1)H MRS) in women with AN.
  • Examine the relationship between marrow fat composition, bone mineral density (BMD), and body composition.

Main Methods:

  • (1)H MRS to assess femoral diaphysis marrow fat and soleus intramyocellular lipids in 14 women with AN and 12 controls.
  • MRI for abdominal and thigh fat/muscle areas; DXA for lumbar spine BMD, fat, and lean mass.

Main Results:

  • Women with AN exhibited higher total femoral marrow fat content compared to controls (p<0.05).
  • Marrow fat composition was similar between groups (p>0.05).
  • Marrow FA saturation inversely correlated with lumbar spine BMD (r=-0.52, p=0.008), independent of %ideal body weight.

Conclusions:

  • Women with AN have increased femoral marrow fat but similar marrow fat composition.
  • Increased marrow fatty acid (FA) saturation is linked to lower BMD, suggesting a negative impact on bone health.
  • Marrow FA unsaturation correlates with muscle lipid unsaturation, indicating shared influencing factors.