The single nucleotide polymorphism rs2208454 confers an increased risk for ischemic stroke: a case-control study

Area of Science:

• Genetics
• Neurology
• Epidemiology

Background:

• A prior genome-wide association study linked covert magnetic resonance imaging infarcts to single nucleotide polymorphism (SNP) rs2208454.
• Ischemic stroke (IS) poses a significant global health burden, necessitating identification of genetic risk factors.

Purpose of the Study:

• To investigate the association between the rs2208454 polymorphism and the risk of ischemic stroke (IS).
• To determine if rs2208454 is a risk factor for IS in a southern Chinese Han population.

Main Methods:

• Case-control study design including 712 IS patients and 774 controls from a southern Chinese Han population.
• Genotyping was performed using the snapshot technique.
• Statistical analysis included logistic regression adjusted for age, gender, and relevant medical histories.

Main Results:

• The TT genotype of SNP rs2208454 was significantly more frequent in IS patients compared to controls (p < 0.05).
• Adjusted analysis confirmed a persistent association between the TT genotype and IS risk (OR = 1.79-1.88).
• Subgroup analysis revealed a significant association of SNP rs2208454 with large artery atherosclerosis (LAA) IS subtype (OR = 2.16).

Conclusions:

• The rs2208454 polymorphism is a significant risk factor for ischemic stroke in the southern Chinese Han population.
• The genetic risk conferred by rs2208454 is primarily associated with the large artery atherosclerosis subtype of IS.