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Anticoagulation therapy is harmful to large-sized cerebellar infarction
She-Qing Zhang1, Wei Wang, Xiao-Long Ma
1Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai, China.
CNS Neuroscience & Therapeutics
|June 24, 2014
Summary
Anticoagulation therapy may harm patients with large cerebellar infarction. Studies showed increased mortality and adverse effects in both human and animal models, suggesting caution when using these drugs for cerebellar stroke.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Pharmacology
Background:
- Anticoagulants are standard treatments for ischemic stroke.
- The specific effects of anticoagulation on cerebellar infarction remain unclear.
- Cerebellar infarction can lead to significant neurological deficits.
Purpose of the Study:
- To investigate the impact of anticoagulation therapy on large-sized cerebellar infarction.
- To evaluate the safety and efficacy of anticoagulants in this specific patient population.
Main Methods:
- A clinical study reviewed 30 patients with large cerebellar infarction (diameter > 3 cm) treated with or without anticoagulation.
- An animal study involved 12 Cynomolgus monkeys with induced cerebellar infarction, treated with low molecular weight heparin (LMWH) or vehicle for 14 days.
Main Results:
- In the clinical study, all six deaths occurred in patients receiving anticoagulation.
- In the animal study, 33% of LMWH-treated monkeys died, compared to 0% in the vehicle group.
- LMWH treatment led to worsened neurological scores, increased cerebellar water content, and induced edema, hemorrhage, and subarachnoid hemorrhage.
Conclusions:
- Anticoagulation therapy appears to have detrimental effects on large-sized cerebellar infarction.
- These findings suggest that anticoagulants may increase risks and complications in cerebellar stroke patients.
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