Leucocyte adhesion deficiency III in a mixed-breed dog

Area of Science:

• Veterinary Medicine
• Immunology
• Genetics

Background:

• Leucocyte adhesion deficiencies (LADs) are inherited immune disorders characterized by recurrent infections and high white blood cell counts.
• LAD-III specifically results from impaired beta-integrin activation, affecting neutrophil function and platelet aggregation.

Observation:

• A 16-month-old mixed-breed dog presented with pyrexia, persistent leucocytosis, severe periodontal disease, lameness, mucosal hemorrhages, and poor wound healing.
• Diagnostic workup confirmed a positive PCR test for leucocyte adhesion deficiency III.

Findings:

• The dog was diagnosed with leucocyte adhesion deficiency III, a rare condition previously documented in humans and purebred German Shepherds.
• This case represents the first reported instance of LAD-III in Australia and the first in a mixed-breed dog globally.

Implications:

• This case expands the known breed and geographic distribution of leucocyte adhesion deficiency III.
• Understanding LAD-III in diverse canine populations is crucial for accurate diagnosis and effective management strategies.