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Allergic Reactions

Allergic Reactions

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...

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Updated: Apr 27, 2026

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

Published on: February 13, 2019

[Mosquito allergy].

H Haas¹, A Tran¹

¹Urgences pédiatriques, hôpitaux pédiatriques de Nice, CHU-Lenval, 57, avenue de la Californie, 06200 Nice, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|June 24, 2014

Summary

This summary is machine-generated.

Mosquito saliva contact during blood meals causes frequent allergic reactions, ranging from mild to severe. Recombinant allergens may improve diagnosis and enable immunotherapy for insect bite reactions.

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Published on: January 12, 2017

Area of Science:

Allergology and Immunology
Medical Entomology

Context:

Mosquitoes (Culex, Aedes) are prevalent in moderate climates.
Mosquito saliva exposure during blood meals triggers diverse immunoallergic responses.
Reactions can mimic infectious cellulitis, leading to misdiagnosis and inappropriate antibiotic use.

Purpose:

To describe the clinical spectrum and natural history of mosquito bite reactions.
To evaluate current diagnostic methods (skin prick testing, serum IgE) for mosquito allergies.
To explore the potential of recombinant mosquito salivary allergens for improved diagnostics and immunotherapy.

Summary:

Mosquito saliva exposure during blood meals is a common cause of allergic reactions, varying from pruritic wheals to severe responses.
The natural history involves five stages, potentially leading to immunotolerance.
Current diagnostic tests lack sufficient sensitivity and specificity, limiting their use to severe cases.

Impact:

Highlights the need for accurate diagnosis of mosquito bite hypersensitivity.
Suggests recombinant allergens offer a promising avenue for precise diagnosis and targeted immunotherapy.
Aims to reduce misdiagnosis and inappropriate antibiotic treatments for insect bite reactions.