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Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System
12:18

Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System

Published on: November 6, 2013

23.8K

Identification of Influenza A/H7N9 virus infection-related human genes based on shortest paths in a virus-human

Ning Zhang1, Min Jiang2, Tao Huang3

  • 1Department of Biomedical Engineering, Tianjin University, Tianjin Key Lab of BME Measurement, Tianjin 300072, China.

Biomed Research International
|June 24, 2014
PubMed

Insights

This study identifies 20 key human genes linked to Influenza A/H7N9 infection using a novel computational approach. These genes offer insights into H7N9

Area of Science:

  • Virology
  • Computational Biology
  • Genetics

Background:

  • Influenza A/H7N9 poses a significant human health threat with poorly understood infection mechanisms.
  • Identifying host factors is crucial for understanding viral pathogenesis and developing therapies.

Purpose of the Study:

  • To computationally identify human genes associated with Influenza A/H7N9 virus infection.
  • To provide potential targets for further experimental validation and therapeutic development.

Main Methods:

  • Developed a computational method utilizing the "guilt by association" rule on a virus-human protein interaction network.
  • Identified significant human genes by analyzing shortest paths within the network.
  • Compared H7N9 results with those from human rhinovirus (HRV) and respiratory syncytial virus (RSV).

Main Results:

  • Screened 20 significant human genes potentially related to H7N9 infection.
  • Identified enrichment in protein binding, saccharide/polysaccharide metabolism, and oxidative phosphorylation pathways.
  • Saccharide/polysaccharide metabolism pathways appear particularly associated with H7N9 infection compared to HRV and RSV.

Conclusions:

  • The identified genes and pathways offer a foundation for understanding H7N9 infection mechanisms.
  • Findings guide future experimental studies and the development of clinical strategies for H7N9.
  • Highlights the potential role of host metabolic pathways in H7N9 pathogenesis.

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