Sleep Disorders in Atypical Parkinsonism
Sabra M Abbott1, Aleksandar Videnovic2
1Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Movement Disorders Clinical Practice
|June 24, 2014
Summary
Sleep disorders like REM sleep behavior disorder are common in atypical parkinsonism. Specific sleep issues can help diagnose multiple system atrophy, dementia with Lewy bodies, and progressive supranuclear palsy.
Area of Science:
- Neurology
- Sleep Medicine
- Neurodegenerative Diseases
Background:
- Sleep disorders are prevalent in atypical parkinsonism, varying by specific condition.
- Nocturnal stridor and REM sleep behavior disorder (RBD) are key features in multiple system atrophy (MSA).
- RBD is also seen in dementia with Lewy bodies (DLB), while less common in progressive supranuclear palsy (PSP).
Purpose of the Study:
- To review sleep dysfunction across atypical parkinsonian disorders.
- To highlight the importance of assessing sleep disorders in parkinsonian patients.
- To identify sleep characteristics as diagnostic clues for underlying parkinsonian disorders.
Main Methods:
- Review of literature on sleep disorders in atypical parkinsonism.
- Analysis of specific sleep abnormalities associated with MSA, DLB, PSP, and corticobasilar degeneration (CBD).
- Correlation of sleep characteristics with diagnostic features of these neurodegenerative conditions.
Main Results:
- Nocturnal stridor is highly specific to MSA.
- RBD is common in MSA and DLB, but less so in PSP.
- Insomnia and altered sleep architecture are prevalent in PSP; CBD has fewer associated sleep complaints.
Conclusions:
- Sleep disturbances are significant indicators in atypical parkinsonism.
- Distinct sleep patterns can aid in differentiating between MSA, DLB, PSP, and CBD.
- Systematic evaluation of sleep is crucial for accurate diagnosis and management of parkinsonian disorders.
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