Related Experiment Video

Updated: Apr 27, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

24.3K

[Severe Staphylococcus aureus infections: clinical characteristics, antibiotic susceptibility and use of

Juan Eduardo Ves Losada1, Ana Paula Graziano1, Maximiliano De Abreu2

  • 1Cuidados Intermedios Pediátricos, Hospital El Cruce.

Archivos Argentinos De Pediatria
|June 24, 2014
PubMed

Insights

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections pose a significant public health challenge. This case series highlights CA-MRSA infections in pediatric patients, noting increased critical care days and secondary infections.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Context:

  • Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections represent a growing global health concern.
  • These infections place a substantial burden on healthcare systems worldwide.
  • The optimal initial antibiotic treatment for severe CA-MRSA infections remains a subject of ongoing debate.

Purpose:

  • To present a case series of hospitalized pediatric patients with severe Staphylococcus aureus infections.
  • To analyze the characteristics and outcomes of CA-MRSA infections in a pediatric intermediate care unit.

Summary:

  • A total of 43 pediatric patients with severe Staphylococcus aureus infections were admitted between May 2008 and December 2010.
  • Sixty-nine percent of isolated Staphylococcus aureus strains were methicillin-resistant.
  • While not statistically significant, CA-MRSA infections were associated with longer critical care unit hospitalization and more secondary infection sites.

Impact:

  • The study underscores the prevalence of CA-MRSA in severe pediatric infections.
  • It highlights the need for effective treatment strategies, noting high resistance to p-lactams.
  • Vancomycin, rifampicin, and clindamycin were frequently used, indicating their role in managing these infections.

More Related Videos

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus08:32

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

1.3K
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.2K

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
85
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
138
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
211
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
2.9K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
832
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2.3K