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Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An "ab initio" Study
Manuela Curcio1, Giuseppe Cirillo2, Ortensia Ilaria Parisi3
1Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende (CS), Italy. manuela.curcio@unical.it.
Abstract:
A novel polymeric material with antioxidant properties and suitable for ophthalmic application was synthesized by free radical grafting reaction between 2-hydroxyethyl methacrylate and quercetin. The presence of quercetin in the polymeric chain was confirmed by FT-IR and UV-Vis analyses, while an estimation of the amount of quercetin bound per gram of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows high biocompatibility (HET-CAM assay) and antioxidant and anti-inflammatory properties which were extensively investigated by specific in vitro tests.
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