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Controlled release from recombinant polymers.

Robert Price1, Azadeh Poursaid2, Hamidreza Ghandehari3

  • 1Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|June 24, 2014
PubMed
Summary
This summary is machine-generated.

Recombinant polymers offer precise control over drug release due to their defined molecular structure. Genetic engineering allows for tailored properties, advancing controlled delivery applications.

Keywords:
Controlled releaseElastin-like Polypeptides (ELP)Recombinant Cationic Polymers (RCP)Recombinant polymersSilk-elastinlike Protein Polymers (SELP)Silk-like Polypeptides (SLP)

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Recombinant polymers offer precise molecular definition for controlled release applications.
  • Amino acid building blocks provide advantages like biorecognition, biodegradability, and tunable mechanical properties.
  • Genetic engineering enables optimization of polymer structure for controlled spatial and temporal release.

Purpose of the Study:

  • To review the progress and prospects of recombinant polymers in controlled release applications.
  • To highlight the advantages of recombinant DNA technology over chemical synthesis for polymer production.
  • To discuss various classes of recombinant polymers used in drug and gene delivery.

Main Methods:

  • Utilizing genetic engineering and DNA manipulation techniques to design and produce recombinant polymers.
  • Employing recombinant DNA technology for the synthesis of monodisperse polymers with defined sequences.
  • Investigating various classes of recombinant polymers, including elastin-like, silk-like, and silk-elastinlike proteins.

Main Results:

  • Recombinant polymers allow for a high degree of molecular definition, enabling structure-function correlations in controlled release.
  • These polymers exhibit desirable attributes such as biorecognition, biodegradability, and biocompatibility.
  • Monodisperse polymers with specifically defined sequences can be produced, offering superior control compared to chemically synthesized polymers.

Conclusions:

  • Recombinant polymers represent a powerful platform for advanced controlled release systems.
  • The ability to precisely engineer polymer architecture facilitates tailored drug and gene delivery.
  • Future prospects involve further development and application of these engineered biomaterials in medicine.