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[Hyperthyroidism and its relation to heart function].

H Marek1, K Kellner, H J Duck

  • 1Klinik für Innere Medizin, Bereiches Medizin, Karl-Marx-Universität Leipzig.

Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|January 15, 1989
PubMed
Summary
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Hyperthyroidism impacts cardiac function, affecting heart rate and ventricle filling, particularly in younger patients. Echocardiography and myocardial scintigraphy reveal kinetic and perfusion disturbances, while catecholamine levels remain normal.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nuclear Medicine

Context:

  • Hyperthyroidism, a condition of excess thyroid hormone, significantly impacts cardiovascular function.
  • Assessing cardiac function in hyperthyroid patients requires a multi-modal approach, integrating various imaging and invasive techniques.

Purpose:

  • To investigate the influence of hyperthyroidism on cardiac function using both non-invasive and invasive methods.
  • To evaluate cardiac kinetic and perfusion disturbances in hyperthyroid patients.

Summary:

  • Non-invasive methods (radiocardiography, echocardiography, Tc-99m- and Tl-201-myocardial scintigraphy) and invasive coronary angiography were used to study cardiac function in hyperthyroidism.
  • Increased heart rate was observed in all patients, while younger patients showed significant increases in ventricular filling, stroke index (SI), and heart index (HI).

Related Experiment Videos

  • Echocardiography identified local and global kinetic disturbances, and Tl-201 myocardial scintigraphy revealed myocardial perfusion issues. Plasma catecholamine levels were within the lower normal range.
  • Impact:

    • This study highlights the diverse cardiac manifestations of hyperthyroidism, emphasizing age-dependent effects on cardiac hemodynamics.
    • The findings underscore the utility of advanced imaging techniques in diagnosing and understanding cardiac dysfunction in endocrine disorders.
    • Understanding the impact of thyroid hormones on beta-adrenoceptors and myocardial energy metabolism provides insights into therapeutic strategies.