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[Hyperthyroidism and its relation to heart function]
1Klinik für Innere Medizin, Bereiches Medizin, Karl-Marx-Universität Leipzig.
Insights
Hyperthyroidism impacts cardiac function, affecting heart rate and ventricle filling, particularly in younger patients. Echocardiography and myocardial scintigraphy reveal kinetic and perfusion disturbances, while catecholamine levels remain normal.
Area of Science:
- Cardiology
- Endocrinology
- Nuclear Medicine
Context:
- Hyperthyroidism, a condition of excess thyroid hormone, significantly impacts cardiovascular function.
- Assessing cardiac function in hyperthyroid patients requires a multi-modal approach, integrating various imaging and invasive techniques.
Purpose:
- To investigate the influence of hyperthyroidism on cardiac function using both non-invasive and invasive methods.
- To evaluate cardiac kinetic and perfusion disturbances in hyperthyroid patients.
Summary:
- Non-invasive methods (radiocardiography, echocardiography, Tc-99m- and Tl-201-myocardial scintigraphy) and invasive coronary angiography were used to study cardiac function in hyperthyroidism.
- Increased heart rate was observed in all patients, while younger patients showed significant increases in ventricular filling, stroke index (SI), and heart index (HI).
- Echocardiography identified local and global kinetic disturbances, and Tl-201 myocardial scintigraphy revealed myocardial perfusion issues. Plasma catecholamine levels were within the lower normal range.
Impact:
- This study highlights the diverse cardiac manifestations of hyperthyroidism, emphasizing age-dependent effects on cardiac hemodynamics.
- The findings underscore the utility of advanced imaging techniques in diagnosing and understanding cardiac dysfunction in endocrine disorders.
- Understanding the impact of thyroid hormones on beta-adrenoceptors and myocardial energy metabolism provides insights into therapeutic strategies.
Abstract:
The influence of hyperthyreosis on the cardiac function was investigated by means of non-invasive methods (radiocardiography, echocardiography, Tc-99m- und Tl-201-scintigraphy of the myocardium) and invasive methods (coronary angiography). Independent of age an increase of the frequency was always existing, a significant increase of the filling of the ventricle, of SI and HI was shown only by younger patients. With the help of the echocardiography local and global disturbances of kinetics, by means of the Tl-201-scintigraphy of the myocardium disturbances of the myocardial perfusion could be proved. For the circulating plasma catecholamines noradrenalin, adrenalin and dopamine values were established lying in the lower region of the normal. The effects of an increase of the thyroid hormone on the number and/or sensitivity of the membrane-bound beta-adrenoceptors of the heart as well as the independent of its effect of the SDH on the obtaining of myocardial energy are discussed.