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Updated: Apr 27, 2026

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing
Published on: February 13, 2016
A model for transport phenomena in a cross-flow ultrafiltration module with microchannels
Aiko Nishimoto1, Shiro Yoshikawa2, Shinichi Ookawara3
1Department of Chemical Engineering Graduate School for Science and Engineering, Tokyo Institute of Technology, Meguro-ku, Tokyo, 152-8550, Japan. aiko_nishimoto@ihi.co.jp.
Microchannel cross-flow ultrafiltration offers efficient macromolecule separation. Permeate flux is influenced by transmembrane pressure, flow rate, and concentration, with experimental results aligning with a developed transport model.
Area of Science:
- Chemical Engineering
- Separation Science
- Membrane Technology
Background:
- Microchannel cross-flow ultrafiltration modules offer advantages like enhanced diffusion and high surface area-to-volume ratios.
- These modules are promising for separation, refining, and as membrane reactors in microchemical processes.
- Limited research exists on the performance of microchannel ultrafiltration modules.
Purpose of the Study:
- To investigate the relationship between operational conditions and the performance of microchannel cross-flow ultrafiltration devices.
- To model the transport phenomena within the microchannel and membrane permeation.
Main Methods:
- Utilized Poly Vinyl Pyrrolidone (PVP) aqueous solution as a model macromolecular solute.
- Conducted cross-flow ultrafiltration experiments under constant pressure, varying transmembrane pressure, feed flow rate, and feed concentration.
- Developed a transport phenomena model based on concentration and velocity distributions.
Main Results:
- Permeate flux initially decreased, then stabilized to a constant value.
- Permeate flux increased with higher transmembrane pressure and feed flow rate.
- Permeate flux decreased with increased feed liquid concentration.
- Experimental data showed good agreement with the developed transport model.
Conclusions:
- Established a clear correlation between operational parameters and ultrafiltration performance in microchannels.
- Validated the predictive capability of the developed transport model for microchannel ultrafiltration.
- Highlighted the potential of microchannel modules for efficient macromolecular separation processes.
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