Related Experiment Video
Updated: Apr 27, 2026
09:29
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
1.8K
Maintenance treatments for opiate -dependent adolescents
Silvia Minozzi1, Laura Amato, Cristina Bellisario
1Department of Epidemiology, Lazio Regional Health Service, Via di Santa Costanza, 53, Rome, Italy, 00198.
The Cochrane Database of Systematic Reviews
|June 25, 2014
Summary
Pharmacological maintenance treatment for adolescents shows promise in retaining them in care and reducing opioid use. However, more research is urgently needed due to limited evidence from just two trials.
Area of Science:
- Addiction Medicine
- Adolescent Health
- Pharmacotherapy
Background:
- Pharmacotherapy is crucial for opioid-dependent adults.
- Limited systematic reviews exist on pharmacological maintenance treatment for adolescents.
Purpose of the Study:
- To assess the effectiveness of maintenance treatments for adolescent opioid dependence.
- Evaluated retention in treatment, substance use reduction, and health/social status improvement.
Main Methods:
- Systematic review of randomized controlled trials.
- Searched multiple databases up to January 2014.
- Included trials comparing maintenance treatment with other interventions in adolescents (13-18 years).
Main Results:
- Two trials (189 participants) were included: methadone vs. LAAM, and buprenorphine-naloxone maintenance vs. detoxification.
- Buprenorphine maintenance improved treatment retention and reduced self-reported opioid use.
- Evidence quality was low to very low; no serious side effects reported.
Conclusions:
- Limited evidence from two trials makes definitive conclusions difficult.
- Further randomized controlled trials with long follow-up are urgently needed.
- Future research should compare maintenance with detoxification or psychosocial treatments.
Related Concept Videos
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
1.5K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.5K
01:24Operant Conditioning Intervention
725
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
In operant conditioning, behaviors that are...
725
01:26Pharmaceutical Poisoning: Treatment Strategies
271
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
271
01:28Drug Therapy
445
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
445
01:20Opioid Analgesics: Morphine and Other Natural Cogeners
1.6K
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
1.6K
01:25Analgesia and Pain Management
3.3K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
3.3K