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ESCRT: nipping the wound in the bud?
T Castro-Gomes1, A B Koushik1, N W Andrews1
1Department of Cell Biology and Molecular Genetics, 2134 Bioscience Research Building, University of Maryland, College Park, MD 20742-5815, USA.
Trends in Biochemical Sciences
|June 25, 2014
Abstract:
Rapid repair of plasma membrane wounds is critical for cellular survival. Exocytic patches, membrane tension reduction and endocytosis were previously proposed to mediate resealing. A recent study implicating the ESCRT complex adds to the growing evidence that repair involves removal of damaged plasma membrane, and not simply patching the wound.
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