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Related Experiment Videos

Intestinal permeability in Crohn's disease.

M S Murphy1, E J Eastham, R Nelson

  • 1Department of Child Health, University of Newcastle upon Tyne.

Archives of Disease in Childhood
|March 1, 1989
PubMed
Summary

Measuring intestinal permeability using lactulose and mannitol can help diagnose Crohn's disease, especially when symptoms are unclear. This non-invasive test accurately assesses disease activity and severity.

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Area of Science:

  • Gastroenterology
  • Clinical Diagnostics
  • Biomarkers

Background:

  • Crohn's disease diagnosis can be delayed due to insidious onset, particularly in children.
  • Clinical assessment of Crohn's disease activity may lack accuracy.

Purpose of the Study:

  • To evaluate intestinal permeability as a diagnostic and assessment tool for Crohn's disease.
  • To correlate intestinal permeability with disease activity index in Crohn's disease patients.

Main Methods:

  • Cross-sectional study involving 17 active Crohn's disease patients and 31 controls.
  • Intestinal permeability assessed using urinary excretion ratio of lactulose and mannitol probe molecules.
  • Disease activity evaluated using a standardized activity index score.

Main Results:

  • Significantly increased lactulose:mannitol urinary excretion ratio observed in Crohn's disease patients.
  • High sensitivity for detection: 82% overall, 92% for moderate to severe activity.
  • Significant correlation found between intestinal permeability and disease activity index in cross-sectional and longitudinal studies.

Conclusions:

  • Intestinal permeability measurement is a non-invasive, sensitive tool for Crohn's disease.
  • This method can aid in screening patients with non-specific symptoms.
  • It provides a reliable assessment of disease activity extent in Crohn's disease.

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