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Canthaxanthin retinopathy. Anatomic and functional reversibility.

C Harnois1, J Samson, M Malenfant

  • 1Department of Ophthalmology, CHUL Research Center, Laval University Medical Center, Quebec, Canada.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|April 1, 1989
PubMed
Summary

Canthaxanthin retinopathy, marked by retinal deposits, showed slow but significant reversibility over time. Deposits gradually disappeared, with some persisting for up to seven years after discontinuing canthaxanthin intake.

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Area of Science:

  • Ophthalmology
  • Toxicology
  • Retinal research

Background:

  • Canthaxanthin intake can lead to golden yellow crystalline deposits in the retina.
  • These deposits are associated with reduced visual function, specifically a lower static luminance threshold.

Purpose of the Study:

  • To assess the anatomical and functional reversibility of canthaxanthin retinopathy.
  • To determine the timeline for the resolution of retinal deposits and visual function recovery.

Main Methods:

  • Nine patients with canthaxanthin retinopathy were monitored over a mean of 55 months.
  • Retinal deposit counts were evaluated multiple times.
  • Threshold static perimetry was used to assess visual function in patients and controls.

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Main Results:

  • No significant difference in retinal deposits was observed at nine months.
  • A statistically significant decrease in retinal deposits occurred after 26 months.
  • Deposits resolved slowly, with some remaining visible up to seven years post-cessation.
  • Visual function, measured by threshold static perimetry, did not significantly differ between patients and controls post-follow-up.

Conclusions:

  • Canthaxanthin retinopathy is a reversible condition.
  • While deposits resolve over time, complete resolution may take several years.
  • Visual function appears to recover to normal levels despite the presence of residual deposits.