Related Experiment Video
Updated: Apr 27, 2026
10:45
Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
Published on: June 13, 2018
10.1K
[Superficial skin infections and bacterial dermohypodermitis]
M Lorrot1, E Bourrat2, C Doit3
1Groupe de pathologie infectieuse pédiatrique de la Société française de pédiatrie, 94100 Saint-Maur-des-Fossés, France; Service de pédiatrie générale, hôpital Robert-Debré, AP-HP, université Paris Diderot, Sorbonne Paris Cité, UMRS 1123 ECEVE, 48, boulevard Sérurier, 75019 Paris, France.
Summary
Pediatric skin infections caused by Staphylococcus aureus and Streptococcus pyogenes require targeted antibiotic treatment. Mild cases benefit from topical mupirocin or fucidic acid, while severe infections necessitate systemic amoxicillin-clavulanate, potentially with clindamycin for toxic complications.
Area of Science:
- Pediatric infectious diseases
- Bacteriology
- Dermatology
Context:
- Staphylococcus aureus and Streptococcus pyogenes are primary pathogens in pediatric skin infections.
- Effective management strategies are crucial for preventing complications.
Purpose:
- To outline appropriate antibiotic therapies for pediatric skin infections.
- To differentiate treatment approaches based on infection severity and bacterial etiology.
Summary:
- Mild pediatric skin infections, such as impetigo and furunculosis, are best treated with topical antibiotics like mupirocin or fucidic acid.
- Empirical antimicrobial therapy for dermohypodermitis involves oral or parenteral amoxicillin-clavulanate.
- For complicated dermohypodermitis with risk factors for spread, sepsis, or rapid progression, amoxicillin-clavulanate is indicated.
- Clindamycin is recommended as an adjunct to beta-lactam therapy in cases of toxic shock, necrotizing soft tissue infections, or fasciitis.
Impact:
- Provides clear treatment guidelines for common pediatric skin infections.
- Aids clinicians in selecting appropriate antibiotic regimens, optimizing patient outcomes.
- Contributes to the judicious use of antibiotics in pediatric populations.
Related Concept Videos
01:23Skin Diseases and Disorders
5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
01:29Staphylococcal Skin Infections
138
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
138
01:27Acne Infection
91
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
91
01:27The Skin Microbiota
119
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
119
01:21Accessory Structures of the Skin: Sebaceous Glands
5.5K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
5.5K
01:11Papillary Dermis
5.8K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.8K