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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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The oligometastatic state - separating truth from wishful thinking.

David A Palma1, Joseph K Salama2, Simon S Lo3

  • 1Division of Radiation Oncology, London Health Sciences Centre, 790 Commissioners Road East, London, ON N6A 4L6, Canada.

Nature Reviews. Clinical Oncology
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PubMed
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This summary is machine-generated.

The oligometastatic paradigm suggests aggressive treatment of limited metastatic lesions may prolong survival. However, current evidence is insufficient to confirm treatment benefits over patient selection, necessitating further research.

Area of Science:

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