Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroglobulin structure and function: recent advances.

Y Malthièry1, C Marriq, J L Bergé-Lefranc

  • 1Laboratoire de Biochimie Médicale, INSERM U38, CNRS UA178, Faculté de Médecine, Marseille, France.

Biochimie
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictive Value of Asphericity in Pretherapeutic [<sup>111</sup>In]DTPA-Octreotide SPECT/CT for Response to Peptide Receptor Radionuclide Therapy with [<sup>177</sup>Lu]DOTATATE.

Molecular imaging and biology·2016
Same author

Adenosine plasma level correlates with homocysteine and uric acid concentrations in patients with coronary artery disease.

Canadian journal of physiology and pharmacology·2016
Same author

Success of interventions in mastitis problems with Staphylococcus aureus after the introduction of an automatic milking system.

Schweizer Archiv fur Tierheilkunde·2016
Same author

Low basal expression of A2A adenosine receptors and increase in adenosine plasma concentration are associated with positive exercise stress testing.

International journal of cardiology·2014
Same author

Antimicrobial susceptibility of mastitis pathogens of dairy cows in Switzerland.

Schweizer Archiv fur Tierheilkunde·2014
Same author

Paraneoplastic dermatomyositis with glycogen accumulation in muscle.

Revue neurologique·2014
Same journal

Differential cardiac microRNA expression in anoxic Trachemys scripta elegans turtles.

Biochimie·2026
Same journal

Renal failure-driven luminal ammonia production impairs gut barrier function in CKD.

Biochimie·2026
Same journal

Conditional Knockout of Indoleamine 2, 3-Dioxygenase-1 in Osteoprogenitor Cells in Mice Results in Sex-dependent Differences in Bone Mass.

Biochimie·2026
Same journal

Sedentariness disrupts, while exercise restores, thermogenic and metabolic plasticity in inguinal adipose tissue of mice.

Biochimie·2026
Same journal

Chrononutrition as a modulator of retinal metabolic resilience: A translational framework linking circadian biology to ocular disease.

Biochimie·2026
Same journal

Heterologous expression, purification, and biophysical characterisation of the cobalt-dependent nitrile hydratase from Rhodococcus rhodochrous ATCC BAA-870.

Biochimie·2026
See all related articles

Thyroglobulin, a key protein in thyroid hormone synthesis, has unique structural features revealed by DNA studies. Understanding its structure-function relationships is crucial for insights into thyroid diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Thyroglobulin is a thyroid-specific iodoglycoprotein essential for thyroid hormone synthesis.
  • Recent advancements in recombinant DNA technology have enhanced understanding of thyroglobulin's structure and function.

Purpose of the Study:

  • To analyze the primary structure of human thyroglobulin monomer.
  • To investigate structure-function relationships and molecular mechanisms of thyroid hormone formation.
  • To explore the evolutionary and pathological significance of thyroglobulin.

Main Methods:

  • Analysis of the primary structure of human thyroglobulin monomer.
  • Comparative sequence analysis with bovine and other mammalian thyroglobulins.
  • Identification of homologies with non-thyroid proteins like acetylcholinesterase.

Related Experiment Videos

Main Results:

  • Identified three types of internal homologies within the human thyroglobulin monomer.
  • Demonstrated extensive homology with bovine thyroglobulin and significant similarities with other mammalian species.
  • Revealed significant homologies with acetylcholinesterase and the invariant chain of Ia class II histocompatibility antigen.
  • Located hormonogenic sites at both terminal ends of the thyroglobulin monomer.

Conclusions:

  • The structural analysis provides insights into thyroglobulin's role in thyroid hormone synthesis.
  • Further research on thyroglobulin's conformation and interactions is needed to understand hormone formation.
  • Knowledge of thyroglobulin is vital for understanding genetic and autoimmune thyroid diseases.