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Published on: February 19, 2019
Acute liver failure caused by severe acute hepatitis B: a case series from a multi-center investigation
Chun-Ya Wang, Pan Zhao1, Wei-Wei Liu
1Clinical Trial Center, Liver Failure Therapy and Research Center, Beijing 302 Hospital (PLA 302 Hospital), No,100 of West Fourth Ring Middle Road, Beijing 100039, China. doczhaopan@126.com.
Background:
Few data can be available regarding acute liver failure (ALF) caused by severe acute hepatitis B up to now. This study aims to report such cases from China.
Findings:
We conducted a multi-center investigation on ALF from 7 tertiary hospitals in different areas of China. A total of 11 patients with ALF caused by severe acute hepatitis B were finally identified. In these patients, there were 10 male and 1 female patients. As a serious complication, apparent hemorrhage occurred in 9 patients. Eventually, in these 11 patients, 4 survived and 7 died. 4 died of heavy bleeding, 2 died of systemic inflammatory response syndrome and 1 died of irreversible coma. No patients received liver transplantation.
Conclusions:
ALF caused by severe acute hepatitis B is worthy of formal studies based on its rarity and severity.
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