Coexisting glomerular IgA deposition and IgG-kappa multiple myeloma

Area of Science:

• Nephrology
• Oncology
• Immunology

Background:

• Multiple myeloma (MM) frequently causes kidney damage due to abnormal immunoglobulin deposition.
• Renal involvement in MM can manifest in various forms, impacting patient prognosis.

Observation:

• A case of IgG-kappa type MM presented with concurrent IgA deposition alongside IgG-kappa in the kidneys.
• The patient exhibited mesangial proliferative nephritis.

Findings:

• The patient received treatment with prednisone and mycophenolate mofetil, achieving satisfactory remission.
• This case represents the first documented instance of coexisting mesangial proliferative nephritis with IgA deposition and IgG-kappa type MM.

Implications:

• This unique presentation expands the understanding of kidney pathologies associated with multiple myeloma.
• Further research is needed to clarify the relationship between IgA deposition and MM in such cases.