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Severe renal failure following high-dose ifosfamide and mesna
P H Willemse1, P E de Jong, J D Elema
1Department of Internal Medicine, University Hospital Groningen, The Netherlands.
Cancer Chemotherapy and Pharmacology
|January 1, 1989
Abstract:
A 62-year-old woman developed subacute renal failure after the repeated administration of ifosfamide (IFX), despite its combination with continuous sodium 2-mercaptoethane sulfonate (mesna) infusion. Biopsy findings, the possible underlying mechanism, and the existing literature are discussed.