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Updated: Apr 27, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
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Published on: January 27, 2013

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New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.

Nichole Coleman1, Brandon M Brown1, Aida Oliván-Viguera1

  • 1Department of Pharmacology (N.C., B.M.B., V.S., H.W.), School of Medicine, and Department of Chemistry (M.M.O.), University of California, Davis, California; Aragon Institute of Health Sciences, Instituto de Investigación Sanitaria, Fundación Agencia Aragonesa para la Investigación y el Desarrollo, Zaragoza, Spain (A.O.-V., R.K.); and Grupo de Investigación del Medio Ambiente del Centro de Estudios Superiores, Faculty of Health Sciences, Universidad San Jorge, Villanueva de Gállego, Spain (M.S.V.).

Molecular Pharmacology
|June 25, 2014
PubMed
Summary

Researchers developed novel compounds, SKA-111 and SKA-121, that selectively activate intermediate-conductance (KCa3.1) calcium-activated potassium channels. SKA-121 demonstrates therapeutic potential for KCa3.1 activation by lowering blood pressure in mice.

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