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Related Experiment Video

Updated: Apr 27, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

When recognition memory is independent of hippocampal function.

Christine N Smith¹, Annette Jeneson², Jennifer C Frascino¹

¹Veterans Affairs San Diego Healthcare System, San Diego, CA 92161;Departments of Psychiatry.

Proceedings of the National Academy of Sciences of the United States of America

|June 25, 2014

Summary

Hippocampal damage spares novel face recognition in patients with hippocampal lesions at short intervals. This suggests alternative brain structures support face memory, challenging broad memory impairment theories.

Keywords:

amnesia long-term memory

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Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

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Published on: June 4, 2020

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

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Published on: August 30, 2017

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Published on: August 20, 2020

Area of Science:

Neuroscience
Cognitive Psychology
Neurology

Background:

Hippocampal damage is traditionally linked to widespread memory deficits.
Recent findings suggest potential sparing of face recognition memory.

Purpose of the Study:

To investigate face recognition memory in patients with hippocampal or medial temporal lobe lesions.
To determine the role of the hippocampus in recognition memory for different stimuli and retention intervals.

Main Methods:

Five experiments were conducted with patients exhibiting hippocampal (H) or medial temporal lobe (MTL) lesions.
Recognition memory was tested for novel faces, words, buildings, inverted faces, and famous faces across varying retention intervals.

Main Results:

Hippocampal patients showed intact recognition of novel faces at short retention intervals.
Recognition memory for words, buildings, inverted faces, and famous faces was impaired in H patients.
MTL patients exhibited impaired recognition memory across all materials and retention intervals.

Conclusions:

Structures beyond the hippocampus, potentially the perirhinal cortex, may support face recognition in H patients under specific conditions.
Hippocampal role in recognition memory may depend on the decision-making process, with face recognition being an exception due to holistic processing and difficulty in verbal labeling.