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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
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Biological Clocks and Seasonal Responses02:45

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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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Insufficient Sleep and Sleep Deprivation01:13

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Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Type II Diabetes I: Introduction01:26

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
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Related Experiment Video

Updated: Apr 27, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Circadian clock desynchronisation and metabolic syndrome.

Mae Sheikh-Ali1, Jaisri Maharaj1

  • 1Department of Medicine, University of Florida College of Medicine, Jacksonville, USA.

Postgraduate Medical Journal
|June 25, 2014
PubMed
Summary

Disrupting your sleep-wake cycle may increase your risk of metabolic syndrome. Aiming for 7-8 hours of quality sleep is crucial for preventing this health condition.

Area of Science:

  • Chronobiology
  • Metabolic Health
  • Sleep Science

Background:

  • Metabolic syndrome incidence has risen alongside decreased sleep duration and quality over the past century.
  • Emerging evidence links circadian rhythm disruption to increased metabolic syndrome risk.
  • Epidemiological and experimental studies suggest a relationship between sleep duration and obesity/diabetes.

Purpose of the Study:

  • To review the emerging evidence linking circadian rhythm disruption to metabolic syndrome.
  • To highlight the potential role of sleep disturbance as a risk factor for metabolic syndrome.
  • To emphasize the need for further research into the pathophysiological pathways.

Main Methods:

  • Literature review of epidemiological studies.
  • Analysis of experimental animal and human studies.

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Related Experiment Videos

Last Updated: Apr 27, 2026

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  • Examination of the relationship between sleep duration/quality and metabolic syndrome components.

    • Main Results:

    • Studies indicate a correlation between reduced sleep duration and increased risk of obesity and diabetes.
    • Optimal sleep duration is suggested to be 7-8 hours per night to prevent circadian disruption.
    • Sleep disturbance, regardless of cause, should be recognized as a metabolic syndrome risk factor.

    Conclusions:

    • Circadian rhythm disruption is a potential risk factor for metabolic syndrome.
    • Maintaining adequate sleep duration (7-8 hours) is recommended for metabolic health.
    • Further research is needed to understand the specific mechanisms of circadian desynchronization and develop interventions.