Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

28
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
28
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

20
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
20
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

20
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
20
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

26
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
26
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

19
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
19

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mathematical modeling of <i>JAK2V617F</i> clonal expansion in a general population cohort.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Osteoarthritis and analgesic consumption in haemochromatosis HFE C282Y homozygotes with normal or low iron parameters.

Nature communications·2026
Same author

Maxillary sinus pyogenic granuloma with orbital extension: a rare pediatric presentation mimicking malignancy.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2026
Same author

Thyroid response to cold activation of brown adipose tissue in Greenlanders and Danes.

European journal of endocrinology·2026
Same author

Endogenous group A streptococcal endophthalmitis mimicking uveitis in a healthy 3-year-old: case report and literature review.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2026
Same author

Atrial Fibrillation in Philadelphia Chromosome-negative Myeloproliferative Neoplasms: Thromboinflammatory Crosstalk with a Focus on the NLRP3 Inflammasome.

Thrombosis and haemostasis·2025

Related Experiment Video

Updated: Apr 27, 2026

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

1.3K

Weight Gain and Serum TSH Increase within the Reference Range after Hemithyroidectomy Indicate Lowered Thyroid

Tina Toft Kristensen1, Jacob Larsen2, Palle Lyngsie Pedersen3

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Koege Hospital, Region Zealand, 4600 Koege, Denmark.

Journal of Thyroid Research
|June 25, 2014
PubMed
Summary
This summary is machine-generated.

Weight gain after hemithyroidectomy may be linked to a decrease in thyroid function, even within normal TSH levels. This study found a correlation between increased TSH and weight gain in patients post-surgery.

More Related Videos

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.5K
Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach
05:10

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Published on: September 15, 2023

2.4K

Related Experiment Videos

Last Updated: Apr 27, 2026

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

1.3K
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.5K
Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach
05:10

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Published on: September 15, 2023

2.4K

Area of Science:

  • Endocrinology
  • Thyroid Surgery
  • Metabolic Studies

Background:

  • Weight gain is a common concern following hemithyroidectomy.
  • The clinical significance of subtle thyroid function changes post-surgery requires further investigation.

Purpose of the Study:

  • To assess body weight changes in patients after hemithyroidectomy.
  • To determine if an increase in thyroid-stimulating hormone (TSH) within the reference range correlates with weight gain.

Main Methods:

  • A controlled follow-up study comparing 28 hemithyroidectomized patients to 47 matched controls.
  • Measurements of serum TSH and body weight were taken preoperatively and two years post-surgery.
  • Analysis included comparisons between patient and control groups, and correlation of TSH levels with weight changes.

Main Results:

  • Hemithyroidectomized patients showed a significant increase in median TSH (1.23 to 2.08 mIU/L) and weight gain (75.0 to 77.3 kg) after two years.
  • Control subjects exhibited stable TSH levels and no significant weight change.
  • TSH increase was significantly correlated with weight gain (r = 0.43, P < 0.01).

Conclusions:

  • Two years post-hemithyroidectomy for benign euthyroid goiter, thyroid function may decrease within the normal laboratory range.
  • Weight gain in biochemically euthyroid patients after hemithyroidectomy could indicate a reduced metabolic rate.