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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Geographical patterns in antimicrobial resistance of acinetobacter in clinical isolates
Naz Perween1, Sonal Sehgal2, S Krishna Prakash3
1Senior Resident, Department of Microbiology, Maulana Azad Medical College , New Delhi, India .
Objectives:
Acinetobacter spp. has emerged as a threat to the healthcare workers throughout the globe, owing to its property of multidrug resistance. The aim of the present study was to evaluate the antimicrobial resistance patterns of Acinetobacter spp. among indoor and out patients in our hospital and compare the resistance patterns in India and abroad.
Materials And Methods:
In this retrospective study, which was carried out between Over a period of one year, a total of 5593 clinical specimens of pus and purulent fluids were examined and antimicrobial resistance pattern for Acinetobacter spp. using Modified Stoke's were evaluated. Also a comparison was done with the other similar studies.
Statistical Analysis:
Using the proportions of sensitive and resistant, the statistical analysis was done. The total, mean and percentage were calculated by using SPSS.
Results:
A high level of antimicrobial multidrug-resistance was found in almost all the clinical isolate. Our study was also found to be concordant with the results of other studies.
Conclusion:
There is an emerging need for identification of the genes and mechanisms for multidrug resistance among Acinetobacter spp.
Insights
Multidrug-resistant Acinetobacter spp. poses a global healthcare threat. This study found high antimicrobial resistance in clinical isolates, highlighting the urgent need to identify resistance mechanisms.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Research
Background:
- Acinetobacter spp. is a significant multidrug-resistant pathogen globally.
- Healthcare-associated infections caused by Acinetobacter spp. are a growing concern.
Purpose of the Study:
- To evaluate antimicrobial resistance patterns of Acinetobacter spp. in indoor and outdoor patients.
- To compare resistance patterns with international data.
Main Methods:
- Retrospective analysis of 5593 clinical specimens (pus and purulent fluids) over one year.
- Antimicrobial resistance patterns determined using Modified Stoke's method.
- Statistical analysis of sensitivity and resistance proportions using SPSS.
Main Results:
- High levels of multidrug-resistance were observed in nearly all clinical isolates.
- The findings are consistent with other similar international studies.
- Acinetobacter spp. demonstrates significant resistance to multiple antimicrobial agents.
Conclusions:
- Urgent need to identify genes and mechanisms conferring multidrug resistance in Acinetobacter spp.
- Understanding resistance mechanisms is crucial for effective treatment strategies.
- Further research into Acinetobacter spp. resistance is warranted.
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